Table 3.
Variables associated with 14-day infection-related mortality.
| Variable | Yes, No. (%) |
No, No. (%) |
P-value |
|---|---|---|---|
| No. of patients | 38 (11.2) | 301 (88.8) | |
| Age in years, median (range) | 68 (38–90) | 64 (23–88) | 0.54 |
| Gender, male | 24 (63.2) | 190 (63.1) | 1.00 |
| Underlying disease/condition | |||
| Cardiovascular disease | 7 (18.4) | 42 (13.9) | 0.46 |
| Diabetes mellitus | 20 (52.6) | 117 (38.9) | 0.12 |
| Uremia requiring dialysis | 7 (18.4) | 59 (19.6) | 1.00 |
| Decompensated liver cirrhosis | 6 (15.8) | 41 (14.6) | 0.80 |
| Malignancies | 7 (18.4) | 57 (18.9) | 1.00 |
| Prosthetic device implantation | 5 (13.2) | 36 (11.9) | 0.79 |
| Severity-of-illness markera | |||
| Nosocomial acquisition | 31 (81.6) | 214 (71.1) | 0.25 |
| Intensive care unit admission | 12 (31.6) | 63 (20.9) | 0.15 |
| APACHE II score, median (range) | 15 (1–38) | 11 (2–29) | 0.15 |
| APACHE II score >15 | 10 (26.3) | 34 (11.3) | 0.02 |
| Source of infectionb | |||
| Catheter-related infection | 1 (2.6) | 39 (12.9) | 0.07 |
| Endovascular infection | 0 | 9 (2.9) | 0.61 |
| Soft-tissue infection | 13 (34.2) | 85 (28.2) | 0.45 |
| Osteomyelitis | 8 (21.1) | 59 (19.6) | 0.83 |
| Urinary tract infection | 0 | 4 (1.3) | 1.00 |
| Pneumonia | 15 (39.5) | 36 (11.9) | <0.01 |
| Primary bacteremia | 6 (15.8) | 68 (22.6) | 0.41 |
| Timing of initiating glycopeptide therapy | |||
| Before preliminary BC report indicated SLO growth and within 24 h after BC indicated SLO growth | 23 (60.5) | 168 (55.8) | 0.61 |
BC: blood culture; MRSA: methicillin-resistant S. aureus; No.: number; SLO: Staphylococcus-like organism.
aAt time of blood culture sampling.
bSome patients had more than one infected site.