Figure 1.

Immunological mechanisms of DNA vaccination in preventing Heymann Nephritis. Antigen encoding sequence is incorporated into a DC-targeted DNA plasmid which contains a scFv sequence encoding for antibodies directed against DEC205. Plasmid DNAs are delivered intramuscularly with electroporation and taken up by DCs. DCs migrate into lymph nodes where they differentiate and induce T cell and B cell responses. B cells differentiate into plasma cells and produce antigen-specific neutralizing antibodies limiting immune activation in chronic kidney disease.