Table 2.
Associations of recent wheeze (cases) with allergen specific IgE (asIgE) and skin prick test reactivity (SPT) to house dust mite and cockroach and anti-Ascaris IgE
| 7–11 years (n = 179) | 12–19 years (n = 197) | Total (N = 376) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Variables | N | Wheeze n(%) | OR (95% CI)* | N | Wheeze n(%) | OR (95% CI) * | N | Wheeze n(%) | OR (95% CI) * | PAF (%) |
| Any asIgE levels (kU/L) | ||||||||||
| < 0.70 | 134 | 64 (48.1) | 1.0 | 137 | 36 (26.3) | 1.0 | 273 | 100 (36.6) | 1.0 | |
| 0.70–3.49 | 26 | 12 (46.2) | 0.75 (0.30–1.86) | 41 | 13 (31.7) | 1.22 (0.55–2.72) | 65 | 25 (38.5) | 1.00 (0.54–1.81) | 0.80 |
| P = 0.534 | P = 0.620 | 0.979 | ||||||||
| ≥ 3.50 | 19 | 13 (68.4) | 1.92 (0.64–5.75) | 19 | 11 (57.9) | 3.80 (1.35–10.76) | 38 | 24 (63.2) | 2.84 (1.34–6.06) | 10.44 |
| P = 0.242 | P = 0.011 | 0.007 | ||||||||
| Any asIgE (≥ 0.70 kU/L) | ||||||||||
| Negative | 134 | 64 (47.8) | 1.0 | 137 | 36 (26.3) | 1.0 | 271 | 100 (36.9) | 1.0 | |
| Positive | 45 | 25 (55.6) | 1.10 (0.53–2.29) | 60 | 24 (40.0) | 1.79 (0.91–3.52) | 105 | 49 (46.7) | 1.47 (0.89–2.41) | 10.52 |
| P = 0.805 | P = 0.089 | P = 0.131 | ||||||||
| asIgE to HDM (≥ 0.70 kU/L) | ||||||||||
| Negative | 152 | 73 (48.0) | 1.0 | 152 | 42 (27.6) | 1.0 | 304 | 115 (37.8) | 1.0 | |
| Positive | 27 | 16 (59.3) | 1.38 (0.56–3.39) | 45 | 18 (40.0) | 1.77 (0.86–3.68) | 72 | 34 (47.2) | 1.64 (0.93–2.89) | 8.91 |
| P = 0.488 | P=0.123 | P = 0.087 | ||||||||
| asIgE to cockroach (≥ 0.70 kU/L) | ||||||||||
| Negative | 151 | 74 (49.0) | 1.0 | 168 | 49 (29.2) | 1.0 | 319 | 123 (38.6) | 1.0 | |
| Positive | 28 | 15 (53.6) | 0.97 (0.41–2.31) | 29 | 11 (37.9) | 1.46 (0.61–3.47) | 17 | 26 (45.6) | 1.20 (0.65–2.23) | 2.91 |
| P = 0.949 | P = 0.396 | P = 0.558 | ||||||||
| Anti-Ascaris IgE (≥ 0.70 kU/L) | ||||||||||
| Negative | 67 | 23 (34.3) | 1.0 | 64 | 11 (17.2) | 1.0 | 131 | 34 (26.0) | 1.0 | |
| Positive | 112 | 66 (58.9) | 2.06 (1.05–4.03) | 133 | 49 (36.8) | 3.00 (1.37–6.56) | 245 | 115 (46.9) | 2.47 (1.50–4.07) | 45.93 |
| P = 0.035 | P = 0.006 | P < 0.001 | ||||||||
| Any SPT (≥ 3 mm) | ||||||||||
| Negative | 154 | 76 (49.4) | 1.0 | 164 | 44 (26.8) | 1.0 | 318 | 120 (37.7) | 1.0 | |
| Positive | 25 | 13 (52.0) | 1.20 (0.48–2.99) | 33 | 16 (48.5) | 2.99 (1.31–6.80) | 58 | 29 (50.0) | 2.05 (1.11–3.78) | 9.97 |
| P = 0.697 | P = 0.009 | P = 0.022 | ||||||||
| SPT to HDM (≥ 3 mm) | ||||||||||
| Negative | 162 | 79 (48.8) | 1.0 | 175 | 49 (28.0) | 1.0 | 337 | 128 (38.0) | 1.0 | |
| Positive | 17 | 10 (58.8) | 1.40 (0.47–4.21) | 22 | 11 (50.0) | 2.76 (1.07–7.13) | 39 | 21 (53.9) | 2.15 (1.04–4.42) | 7.54 |
| P = 0.545 | P = 0.036 | P = 0.038 | ||||||||
| SPT to cockroach (≥ 3 mm) | ||||||||||
| Negative | 169 | 85 (50.3) | 1.0 | 182 | 54 (29.7) | 1.0 | 351 | 139 (39.6) | 1.0 | |
| Positive | 10 | 4 (40.0) | 0.80 (0.19–3.33) | 15 | 6 (40.0) | 1.91 (0.61–6.03) | 25 | 10 (40.0) | 1.37 (0.56–3.34) | 1.81 |
| P = 0.763 | P = 0.269 | P = 0.494 | ||||||||
*
OR estimated by random effects logistic regression model and adjusted by sex, maternal allergic diseases, maternal smoking.
†
OR estimated by random effects logistic regression model and adjusted by age, sex, maternal allergic diseases, maternal smoking.
Any SPT/Any asIgE – SPT or specific IgE for either mite or cockroach.