Table 3.
Associations of wheeze with allergen specific IgE (asIgE) and skin prick test reactivity (SPT) to house dust mite and cockroach stratified by presence of the geohelminth infection markers, Ascaris lumbricoides and/or Trichuris trichiura or anti-Ascaris IgE
| A. lumbricoides and or T. trichiura infection | ||||||
|---|---|---|---|---|---|---|
| Negative (n=112) | Positive (n=251) | |||||
| Wheeze n(%)/N | OR (95% CI) | P-value | Wheeze n(%)/N | OR (95% CI) | P-value | |
| Any asIgE levels (kU/L) | ||||||
| < 0.70 | 23 (31.9)/72 | 1.0 | 73 (38.6)/189 | 1.0 | ||
| ≥ 0.70 | 19 (47.5)/40 | 2.23 (0.81–6.16) | 0.123 | 27 (43.6)/62 | 1.05 (0.56–1.98) | 0.870 |
| Any SPT | ||||||
| Negative | 29 (33.3)/87 | 1.0 | 85 (38.8)/219 | 1.0 | ||
| Positive | 13 (52.0)/25 | 3.52 (1.05–11.79) | 0.041 | 15 (46.9)/32 | 1.59 (0.72–3.54) | 0.253 |
| Anti-Ascaris IgE (kU/L) | ||||||
|---|---|---|---|---|---|---|
| < 0.70 (n = 131) | ≥ 0.70 (n = 245) | |||||
| Wheeze n(%)/N | OR (95% CI) | P-value | Wheeze n(%)/N | OR (95% CI) | P-value | |
| Any asIgE levels (kU/L) | ||||||
| < 0.70 | 28 (24.1)/116 | 1.0 | 72 (46.5)/155 | 1.0 | ||
| ≥ 0.70 | 6 (40.0)/15 | 2.88 (0.84-9.88) | 0.093 | 43 (47.8)/90 | 1.00 (0.56-1.76) | 0.993 |
| Any SPT | ||||||
| Negative | 28 (24.6)/114 | 1.0 | 92 (45.1)/204 | 1.0 | ||
| Positive | 6 (35.3)/17 | 2.53 (0.77–8.27) | 0.125 | 23 (56.1)/41 | 1.96 (0.93–4.12) | 0.075 |
ORs estimated by random effects logistic regression and adjusted by age, sex, maternal smoking and maternal allergic diseases.