TABLE 4.
Characteristics | HR (95% CI) | p | Adjusted HR (95% CI) | p |
---|---|---|---|---|
Mixed Candida/bacterial BSI | 1.09 (0.67–1.78) | 0.72 | – | ND |
Gram-positive bacteria | 0.76 (0.42–1.39) | 0.37 | – | ND |
Gram-negative bacteria | 1.67 (0.86–3.25) | 0.13 | – | 0.15 |
Co-morbidities | ||||
Chronic kidney disease | 2.03 (1.11–3.72) | 0.021 | – | 0.96 |
Charlson co-morbidity index ≥4 | 1.79 (1.13–2.85) | 0.014 | 1.91 (1.17–3.13) | 0.01 |
Risk factors for Candida infectiona | ||||
ICU residence | 1.77 (1.12–2.80) | 0.015 | – | 0.36 |
Neutropenia | 1.46 (0.82–2.62) | 0.20 | – | 0.08 |
Chemotherapy | 1.56 (0.95–2.54) | 0.08 | – | 0.15 |
Corticosteroids | 1.59 (0.94–2.68) | 0.09 | – | 0.27 |
Surgery | 0.46 (0.24–0.88) | 0.02 | 0.34 (0.17–0.65) | 0.001 |
Hyperalimentation | 1.72 (0.83–3.60) | 0.15 | - | 0.31 |
Severity of illness | ||||
SOFA score ≥10 | 3.78 (2.33–6.12) | <0.001 | 3.00 (1.73–5.18) | <0.001 |
Pitt bacteraemia score ≥8 | 4.83 (2.80–8.33) | <0.001 | 6.98 (3.32–14.70) | <0.001 |
Mechanical ventilation | 1.90 (1.19–3.02) | 0.007 | – | 0.76 |
Continuous renal replacement therapy | 1.90 (1.02–3.54) | 0.04 | – | 0.07 |
Delay in initiation of antifungal therapy >72 h | 1.87 (1.16–3.00) | 0.01 | 2.03 (1.23–3.35) | 0.006 |
Early central venous catheter removal | 0.68 (0.41–1.13) | 0.13 | – | 0.99 |
Persistent candidaemia at the last blood culture | 5.87 (3.62–9.52) | <0.001 | 7.60 (4.36–13.25) | <0.001 |
BSI, bloodstream infection; HR, hazard ratio; ICU, intensive care unit; SOFA, sequential organ failure assessment.
Risk factors within 30 days prior to candidaemia.