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. 2013 Jan 21;2013:320168. doi: 10.1155/2013/320168

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Copyright © 2013 Helen Rogers et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Heat-killed Candida-(HKC-) induced IL-23 expression in human monocytes in cell cultures containing LPS. (a) LPS pretreated human PBMC with HKC challenge and expression of mRNA for IL-12p40 and IL-23p19 subunits of IL-23. A significantly increased IL-23 production in an LPS dose-dependent manner was evident compared to cells without LPS stimulation (**P < 0.01). (b) Human monocytes cell line (THP-1) produced IL-23 in a dose-dependent manner in the cell cultures together with LPS. (c) Human PBMC produced IL-17A after days 1, 3, and 7 cultured with 3 different clinical strains of HKC.