Table 1.
List of oncogenes analyzed by the MLPA approach
| Chromosomic Region | Oncogenes | Frequency of tumours with amplifications |
|---|---|---|
| r01p13.2 | NRAS | 25% |
| r01p22.1 | BCAR3 | 0 |
| r01q32 | MDM4 | 0 |
| r03q27 | BCL6 | 0 |
| r05p15.33 | TERT | 31.2% |
| r05q13 | BIRC1 | 12.5% |
| r06p21 | CCND3 | 0 |
| r07q21.3 | CDK6 | 6.2% |
| r08q11 | MOS | 18.8% |
| r11q13 | RELA, GSTP1, CCND1, EMS1, FGF3, | 31.2%* |
| r11q22 | BIRC3 | 6.2% |
| r12p13.32 | CCND2 | 0 |
| r12p13.2 | BCLG | 0 |
| r12q14 | CDK4 | 12.5% |
| r12q14.3 | MDM2 | 12.5% |
| r13q12.3 | CCNA1 | 0 |
| r14q32.33 | AKT1 | 0 |
| r17q25 | BIRC5 | 6.2% |
| r18q21.3 | BCL2 | 0 |
| r19q12 | CCNE1 | 6.2% |
| r20q11.1 | BCL2L1 | 0 |
| r20q13.1 | PTPN1 | 0 |
| r20q13.3 | AURKA | 37.5% |
| r20q13.33 | FLJ20517 | 0 |
| Xq25 | BIRC4 | 0 |
*
Frequency regarding gains of the CCND1 gene