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rPSGL-1 therapy reduces CD45+ cell infiltration in donor specific MHC I antibody-treated allografts.
| Group | Treatment | Hearts with CD45 score ≥2 |
% positive |
Hearts with CD45 score ≥ 3 |
% positive |
p value |
|---|---|---|---|---|---|---|
| 1 | Control mIgG2a | 0/2 | 0% | 0/2 | 0% | |
| 2 | anti-Kd mIgG2a | 4/7 | 57 | 2/7 | 29 |
0.048 versus
group 1 |
| 3 | anti-Kd mIgG2a + rPSGL-1 |
0/4 | 0 | 0/4 | 0 |
0.037 versus
group 2 |
