Skip to main content
. Author manuscript; available in PMC: 2014 Feb 5.
Published in final edited form as: Virology. 2012 Nov 30;436(1):162–172. doi: 10.1016/j.virol.2012.11.005

TABLE 1.

Cellular expression of HSP90AB1 can rescue infection-impaired CA-mutant HIV.

Virus Relative Infectivity (%) to WT HIV
Jurkat E6-1 HSP90AB1 Fold-
Increase		 Hsp90AB1
E42A+D88A
Wild-Type HIV 100 133 ± 11 1.3 83 ± 7
HIV PRI54V+V82A 15 ± 4 69 ± 3 4.6 17 ± 4
HIV CAP38A 6 ± 1 20 ± 4 3.4 8 ± 1
HIV CAE45A 5 ± 1 22 ± 2 4.4 6 ± 1
HIV CAQ63A+Q67A 5 ± 1 23 ± 6 4.6 5 ± 1
HIV CAE128A+R132A 22 ± 3 38 ± 3 1.7 34 ± 4
HIV CAN139A 15 ± 1 81 ± 8 5.4 15 ± 1
HIV CAR143A 17 ± 1 37 ± 3 2.1 13 ± 1

Relative infectivity of WT and mutant HIV in Jurkat E6-1/HSP90AB1 and Jurkat E6-1/HSP90AB1E42A+D88A cells compared to WT HIV infectivity in Jurkat E6-1 cells after 12 days of continuous culture. Results are expressed as mean infectivity ± S.E. for three independent transduction experiments each performed in triplicate.