Table 3.

Growth Inhibition of the OVCAR-8 and NCI/ADR-RES and Messa and Messa/Dx Cell Lines by Compounds 18, 20, 55, and 57 and Reference Compounds VRB, VBL, PTX, 1, and 2^a

compd	IC50 ± SD (nM)			Messa/Dx5b
	OVCAR-8	NCI/ADR-RES	Messab
18	16 ± 6	20 ± 10	7 ± 0.3	13 ± 3
20	28 ± 10	15 ± 7	45 ± 4	39 ± 6
55	17 ± 6	23 ± 10	60 ± 7	71 ± 2
57	7.0 ± 3	14 ± 7	49 ± 2	53 ± 14
1	ndc	ndc	11 ± 6	329 ± 166
2	1.3 ± 0.6	1.3 ± 0.6	2.7 ± 2	2.6 ± 1
VRB	300 ± 0	5000 ± 1000	ndc	ndc
VBL	15 ± 7	200 ± 0	3 ± 2	144 ± 61
PTX	5.0 ± 2	3300 ± 1000	4 ± 1	1764 ± 477

^aInhibition of growth of the indicated cell lines.

^bGrowth inhibition data of compounds 7, 8, 10, 14, 15, 23, 25, 34, and 47 are shown in Supporting Information

^cNo data.