Table 5.

Multivariate logistic regression for predictors of successful empiric therapy

Predictor	Point estimate (OR)	95% confidence limits
Female gender	1.54	0.55; 4.34
colonization with Candida not specified as C. albicans	0.21	0.08; 0.54
Antibiotic use	3.93	0.43; 35.54
Major surgery within 30 days	1.70	0.60; 4.80
Immunosuppressive medication	0.37	0.10; 1.47
Recent parenteral nutrition	0.87	0.33; 2.34
CRRT	0.24	0.08; 0.70
Prior fungal colonization	9.36	1.50; 58.19
Recent use of central venous catheter	1.03	0.06; 16.59
Age ≥ 65 years	0.59	0.23; 1.52
APACHE II score	0.95	0.89; 1.01
Organ transplantation	1.26	0.13; 12.40
Diabetes mellitus	3.08	0.98; 9.70
Mechanical ventilation	0.54	0.17; 1.70
Number of fluconazole treatment cycles	5.60	0.77; 40.67
NeutropeniaANC < 500 cells/mL	4.87	0.57; 41.73

Note: Model predictors were determined based on literature review and expert clinical opinion.

Abbreviations: ANC, absolute neutrophil count; APACHE, Acute Physiology and Chronic Health Evaluation; CRRT, (continuous) renal replacement therapy including hemodialysis; OR, odds ratio.