Table 2.

Risks of TRM, relapse, treatment failure, and overall mortality

Variable	Hazard ratio (95% confidence interval)	P
TRM*
Double UCB vs single UCB	0.91 (0.65-1.27)	.56
Relapse
Double UCB vs single UCB	0.93 (0.55-1.56)	.78
Disease status at transplantation
Second/third vs first CR	1.33 (1.01-1.76)	.05
Relapse vs first CR	3.56 (2.69-4.72)	< .0001
Age, y
21-40 vs 16-20	2.73 (1.51-4.92)	.001
> 40 vs 16-20	2.59 (1.32-5.12)	.006
Conditioning regimen
Non-TBI MAC vs TBI MAC	2.69 (1.68-4.32)	< .0001
Non-TBI RIC vs TBI MAC	1.79 (1.06-3.03)	.03
TBI RIC vs TBI MAC	3.14 (2.13-4.63)	< .0001
Treatment failure (inverse of LFS)
Double UCB vs single UCB	0.97 (0.77-1.22)	.80
Disease status at transplantation
Second/third vs first CR	1.27 (1.04-1.55)	.02
Relapse vs first CR	2.22 (1.78-2.76)	< .0001
Overall mortality
Double UCB vs single UCB	0.93 (0.65-1.33)	.67
Disease status at transplantation
Second/third vs first CR	1.34 (1.05-1.70)	.02
Relapse vs first CR	2.28 (1.83-2.86)	< .0001

CR indicates complete remission; LFS, leukemia-free survival; MAC, myleoablative conditioning; RIC, reduced-intensity conditioning; TBI, total body irradiation; TRM, transplantation-related mortality; and UCB, umbilical cord blood.

^*Stratified for transplantation-conditioning regimen and GVHD prophylaxis.