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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Exp Neurol. 2012 Nov 26;240:9–16. doi: 10.1016/j.expneurol.2012.11.018

Fig. 2.

Fig. 2

Effects of NBO, minocycline and their combination on infarction and hemispheric swelling after 90-min MCAO and 48 hrs of reperfusion. (A) Representative TTC-stained coronal sections showed tissue infarction in the ischemic (right) hemisphere of each treatment group. Veh: vehicle; Mino: minocycline. (B) A greater neuroprotection was observed for the combination therapy compared to NBO or minocycline alone. Infarct volume was quantitated and expressed as a percentage of total brain volume. *P < 0.05 versus Air + Veh; #P < 0.05 versus NBO + Veh or Air + Mino. (C) Only the combination therapy significantly reduced hemispheric swelling. Hemispheric swelling was evaluated as hemispheric enlargement and expressed as the volume ratio between ischemic and nonischemic hemispheres. *P < 0.05 versus Air + Veh. Data are expressed as mean ± SEM, n = 8 for each group.