Figure 1.

Illustration of different prostate biopsy tissue types. Shown are regions of interest (ROIs) taken from the whole-slide images shown in (a) and (b). The following tissue types are illustrated: (c) prostate cancer (CaP) Gleason grade 3, (d) CaP Gleason grade 4, and (e) CaP Gleason grade 5, normal tissue categories (f) benign epithelium and (g) benign stroma, and CaP confounders including (h) prostatic intraepithelial neoplasia (PIN) and (i) tissue atrophy. Note that atrophy and PIN can sometimes be mistaken for CaP and hence pose a diagnostic problem.