Table 3.

Statistical differences between automatic and manual architectural features

Class	p> 0.05	p> 0.01
Epithelium	13	17
Stroma	24	26
Grade 3	6	9
Grade 4	11	15
Grade 5	28	29

Number of architectural features whose values were considered statistically similar between automatically- and manually-detected nuclei by two different criteria (p>0.05 and p>0.01). Stroma and Gleason grade 5 tissue yielded the most similar features, while Gleason grade 3 had the lowest number of similar features.