Table 3.
Target genes of SIM2/ETS2 and their probable function identified by in silico analysis
| Gene IDs | Location | Function (Obtained using Panther Pathway tool) |
|---|---|---|
| A4GALT |
22q13.2 |
Carbohydrate metabolic process, lipid metabolic process, protein metabolic process |
| ABCB8 |
7q36.1 |
Immune system process, extracellular transport, carbohydrate metabolic process, response to toxin |
| ABP1 |
7q36.1 |
Oxidoreductase activity, immune system process, cellular amino acid and derivative metabolic process |
| ATP1A1 |
1p13.1 |
Hydrolase activity, cation transmembrane transporter activity, ion channel activity, cation transport, lipid transport, lipid metabolic process, cellular calcium ion homeostasis |
| ATP1A4 |
1q23.2 |
Cation transport, lipid transport, lipid metabolic process, homeostasis |
| C1QL1 |
17q21.31 |
Complement activation, carbohydrate transport, signal transduction, cell-cell signaling, cell adhesion, carbohydrate metabolic process, lipid metabolic process, cellular component morphogenesis, mesoderm development, skeletal system development, response to stimulus |
| C4BPA |
1q32.2 |
Complement activation, signal transduction, cell-cell adhesion, protein metabolic process, blood coagulation |
| C4BPB |
1q32.2 |
Complement activation, signal transduction, cell-cell adhesion, protein metabolic process, blood coagulation |
| CEACAM1 |
19q13.2 |
Signal transduction, cell-cell adhesion |
| CYB561 |
17q23.3 |
Oxidoreductase activity, respiratory electron transport chain |
| EMCN |
4q24 |
Cell adhesion |
| EXOSC2 |
9q34.12 |
Nucleobase, nucleoside, nucleotide and nucleic acid metabolic process |
| FVT1 |
18q21.3 |
Oxidoreductase activity, metabolic process |
| FXYD5 |
19q13.12 |
Ion channel activity, protein binding ion transport, signal transduction |
| GATA3 |
10p14 |
Hydrolase activity, acting on ester bonds, DNA binding, transcription factor activity nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, endoderm development, heart development, hemopoiesis |
| GNB2L1 |
5q35.3 |
Intracellular protein transport, signal transduction |
| GTF3C5 |
9q34.2 |
DNA binding, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process |
| H1F0 |
22q13.1 |
Nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, organelle organization, establishment or maintenance of chromatin architecture |
| HLA-DOA |
6p21.32 |
Antigen processing and presentation of peptide or polysaccharide antigen via MHC class II, cellular defense response |
| HPD |
12q24.31 |
Cellular amino acid and derivative metabolic process |
| HRB2 |
12q21.2 |
RNA binding, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process |
| KDELR2 |
7p22.1 |
Intracellular protein transport, exocytosis |
| KLK8 |
19q13.41 |
Spermatogenesis, immune system process, cell cycle, protein metabolic process, cell cycle, ectoderm development, nervous system development, blood coagulation |
| KRT16 |
17q21.2 |
Structural constituent of cytoskeleton, ectoderm development, cellular component morphogenesis |
| LCK |
1p35.1 |
Female gamete generation, immune system process, carbohydrate transport, apoptosis, cell cycle, cell surface receptor linked signal transduction, intracellular signaling cascade, carbohydrate metabolic process, protein metabolic process, cell motion, signal transduction, cell-cell signaling, cell-cell adhesion, ectoderm development, mesoderm development, embryonic development, angiogenesis, nervous system development, response to stress |
| LDLR |
19p13.2 |
female gamete generation, cell adhesion |
| LPPR4 |
1p21.2 |
Cell surface receptor linked signal transduction, phosphate metabolic process, lipid metabolic process, signal transduction |
| MAG |
19q13.12 |
Receptor activity, structural constituent of myelin sheath, receptor binding, B cell mediated immunity, cell surface receptor linked signal transduction, cell-cell adhesion, signal transduction, cell-cell adhesion, ectoderm development, nervous system development, response to stimulus |
| MAGEA3 |
Xq28 |
Gamete generation, induction of apoptosis, cell adhesion |
| MAGEE1 |
Xq13.3 |
Gamete generation, induction of apoptosis, cell adhesion |
| MASP1 |
3q27.3 |
Complement activation, protein metabolic process, response to stimulus |
| MLX |
17q21.2 |
DNA binding, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, transcription factor activity |
| MOGAT1 |
2q36.1 |
Acyl-CoA metabolic process, lipid metabolic process |
| MRPL37 |
1p32.3 |
Protein metabolic process |
| MRPS12 |
19q13.2 |
Protein metabolic process |
| NAT5 |
20p11.23 |
Acyltransferase activity, protein metabolic process |
| NDUFA2 |
5q31.3 |
Oxidoreductase activity, oxidative phosphorylation, respiratory electron transport chain |
| PCSK4 |
19p13.3 |
Peptidase activity, cell surface receptor linked signal transduction, cell-matrix adhesion, protein metabolic process, signal transduction |
| PDE6D |
2q37.1 |
Visual perception, sensory perception, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process |
| PRSS8 |
16p11.2 |
Peptidase activity, spermatogenesis, immune system process, protein metabolic process |
| RELA |
11q13.1 |
B cell mediated immunity, negative regulation of apoptosis, cell cycle, intracellular signaling cascade, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, signal transduction, cellular defense response |
| RER1 |
1p36.32 |
Intracellular protein transport |
| S100A8 |
1q21.3 |
Calcium ion binding, receptor binding, calmodulin binding, immune response, macrophage activation, cell cycle, intracellular signaling cascade, cell motion, cell cycle, signal transduction, response to stimulus |
| S100A9 |
1q21.3 |
Immune response, macrophage activation, cell cycle, intracellular signaling cascade, cell motion, cell cycle, signal transduction, response to stimulus |
| SCARB1 |
12q24.31 |
Receptor activity, macrophage activation, lipid transport, apoptosis, signal transduction, cell adhesion, lipid metabolic process, cellular component morphogenesis |
| SERPINA1 |
14q32.13 |
Protein metabolic process |
| SFRS1 |
17q22 |
RNA splicing factor activity, transesterification mechanism, RNA binding, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process |
| SLC25A21 |
14q13.3 |
Cation transport, phosphate transport, lipid transport, nucleobase, nucleoside, nucleotide and nucleic acid transport, phosphate metabolic process, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, lipid metabolic process |
| SLC7A9 |
19q13.11 |
Amino acid transmembrane transporter activity, transmembrane transporter activity amino acid transport, cellular amino acid and derivative metabolic process |
| SP1 |
12q13.13 |
Immune system process, nucleoside, nucleotide and nucleic acid metabolic process |
| TGM2 |
20q11.23 |
Protein metabolic process |
| TH |
11p15.5 |
Oxidoreductase activity, signal transduction, cellular amino acid and derivative metabolic process |
| THBS1 |
15q14 |
Receptor binding, enzyme regulator activity, immune system process, blood coagulation |
| TRFP |
6p21.1 |
Ubiquitin-protein ligase activity |
| TRRAP | 7q22.1 | Immune system process, induction of apoptosis, cell cycle, nucleobase, nucleoside, nucleotide and nucleic acid metabolic process, protein metabolic process, cell cycle, signal transduction, organelle organization, establishment or maintenance of chromatin architecture, response to stress |