Table 6.
Pair wise LD pattern of studied SNPs
|
D′ |
rs6517481 |
rs7276961 |
rs1051475 |
rs1051476 |
rs2070529 |
rs2070530 |
rs2070531 |
rs461155 |
rs11254 |
|---|---|---|---|---|---|---|---|---|---|
| r2 | |||||||||
|
Control | |||||||||
|
rs6517481 |
- |
1 |
0.926 |
0.926 |
0.909 |
0.930 |
0.949 |
0.735 |
0.719 |
|
rs7276961 |
1 |
- |
0.926 |
0.926 |
0.909 |
0.930 |
0.949 |
0.735 |
0.719 |
|
rs1051475 |
0.774 |
0.774 |
- |
1 |
0.899 |
0.923 |
0.944 |
0.765 |
0.722 |
|
rs1051476 |
0.774 |
0.774 |
1 |
- |
0.899 |
0.923 |
0.944 |
0.765 |
0.722 |
|
rs2070529 |
0.499 |
0.499 |
0.441 |
0.441 |
- |
1 |
0.955 |
0.836 |
0.660 |
|
rs2070530 |
0.501 |
0.501 |
0.445 |
0.445 |
0.958 |
- |
0.977 |
0.849 |
0.680 |
|
rs2070531 |
0.902 |
0.902 |
0.805 |
0.805 |
0.551 |
0.553 |
- |
0.757 |
0.718 |
|
rs461155 |
0.366 |
0.366 |
0.362 |
0.362 |
0.622 |
0.615 |
0.389 |
- |
0.612 |
|
rs11254 |
0.491 |
0.491 |
0.503 |
0.503 |
0.250 |
0.255 |
0.490 |
0.240 |
- |
|
Father of DS proband | |||||||||
|
rs6517481 |
- |
1 |
0.856 |
0.853 |
0.871 |
0.954 |
0.905 |
0.907 |
0.845 |
|
rs7276961 |
1 |
- |
0.856 |
0.853 |
0.871 |
0.954 |
0.905 |
0.907 |
0.845 |
|
rs1051475 |
0.579 |
0.579 |
- |
1 |
0.710 |
0.797 |
0.888 |
0.799 |
0.897 |
|
rs1051476 |
0.560 |
0.560 |
0.974 |
- |
0.717 |
0.802 |
0.886 |
0.805 |
0.931 |
|
rs2070529 |
0.423 |
0.423 |
0.369 |
0.387 |
- |
0.974 |
0.956 |
0.807 |
0.876 |
|
rs2070530 |
0.450 |
0.450 |
0.399 |
0.415 |
0.841 |
- |
1 |
0.848 |
1 |
|
rs2070531 |
0.796 |
0.796 |
0.606 |
0.586 |
0.494 |
0.479 |
- |
0.903 |
0.905 |
|
rs461155 |
0.417 |
0.417 |
0.398 |
0.414 |
0.579 |
0.703 |
0.400 |
- |
0.861 |
|
rs11254 |
0.714 |
0.714 |
0.643 |
0.674 |
0.442 |
0.494 |
0.795 |
0.376 |
- |
|
Mother of DS proband | |||||||||
|
rs6517481 |
- |
1 |
0.828 |
0.830 |
0.919 |
0.918 |
0.979 |
0.769 |
0.916 |
|
rs7276961 |
1 |
- |
0.828 |
0.830 |
0.919 |
0.918 |
0.979 |
0.769 |
0.916 |
|
rs1051475 |
0.549 |
0.549 |
- |
1 |
0.658 |
0.671 |
0.849 |
0.548 |
0.926 |
|
rs1051476 |
0.563 |
0.563 |
0.981 |
- |
0.679 |
0.693 |
0.849 |
0.571 |
0.927 |
|
rs2070529 |
0.538 |
0.568 |
0.346 |
0.362 |
- |
1 |
1 |
0.745 |
0.918 |
|
rs2070530 |
0.528 |
0.528 |
0.346 |
0.363 |
0.982 |
- |
1 |
0.750 |
0.916 |
|
rs2070531 |
0.920 |
0.920 |
0.552 |
0.565 |
0.612 |
0.601 |
- |
0.759 |
0.937 |
|
rs461155 |
0.370 |
0.370 |
0.228 |
0.243 |
0.535 |
0.563 |
0.346 |
- |
0.728 |
|
rs11254 |
0.823 |
0.823 |
0.663 |
0.677 |
0.527 |
0.515 |
0.861 |
0.316 |
- |
|
DS proband | |||||||||
|
rs6517481 |
- |
1 |
0.865 |
0.862 |
0.875 |
0.975 |
0.939 |
0.761 |
0.255 |
|
rs7276961 |
1 |
- |
0.865 |
0.862 |
0.875 |
0.975 |
0.939 |
0.761 |
0.255 |
|
rs1051475 |
0.710 |
0.710 |
- |
1 |
0.830 |
0.926 |
0.903 |
0.774 |
0.274 |
|
rs1051476 |
0.680 |
0.680 |
0.966 |
- |
0.807 |
0.903 |
0.885 |
0.756 |
0.266 |
|
rs2070529 |
0.501 |
0.501 |
0.476 |
0.458 |
- |
0.949 |
0.825 |
0.812 |
0.256 |
|
rs2070530 |
0.593 |
0.593 |
0.565 |
0.546 |
0.859 |
- |
0.911 |
0.823 |
0.273 |
|
rs2070531 |
0.754 |
0.754 |
0.735 |
0.718 |
0.523 |
0.608 |
- |
0.699 |
0.269 |
|
rs461155 |
0.375 |
0.375 |
0.410 |
0.404 |
0.659 |
0.645 |
0.376 |
- |
0.167 |
|
rs11254 |
0.039 |
0.039 |
0.043 |
0.039 |
0.026 |
0.028 |
0.037 |
0.011 |
- |
|
ALL | |||||||||
|
rs6517481 |
- |
1 |
1 |
1 |
1 |
1 |
1 |
0.761 |
1 |
|
rs7276961 |
1 |
- |
1 |
1 |
1 |
1 |
1 |
0.761 |
1 |
|
rs1051475 |
0.939 |
0.939 |
- |
1 |
0.926 |
1 |
1 |
0.698 |
1 |
|
rs1051476 |
0.939 |
0.939 |
1 |
- |
0.926 |
1 |
1 |
0.698 |
1 |
|
rs2070529 |
0.698 |
0.698 |
0.638 |
0.638 |
- |
1 |
0.926 |
0.748 |
0.858 |
|
rs2070530 |
0.625 |
0.625 |
0.665 |
0.665 |
0.894 |
- |
1 |
0.731 |
1 |
|
rs2070531 |
0.939 |
0.939 |
1 |
1 |
0.638 |
0.665 |
- |
0.698 |
1 |
|
rs461155 |
0.428 |
0.428 |
0.383 |
0.383 |
0.529 |
0.451 |
0.383 |
- |
0.636 |
|
rs11254 |
0.883 |
0.883 |
0.940 |
0.940 |
0.582 |
0.708 |
0.940 |
0.339 |
- |
|
BC | |||||||||
|
rs6517481 |
- |
1 |
0.884 |
0.884 |
1 |
1 |
1 |
0.5 |
0.122 |
|
rs7276961 |
1 |
- |
0.884 |
0.884 |
1 |
1 |
1 |
0.5 |
0.122 |
|
rs1051475 |
0.741 |
0.741 |
- |
1 |
1 |
1 |
0.884 |
0.891 |
0.077 |
|
rs1051476 |
0.741 |
0.741 |
1 |
- |
1 |
1 |
0.884 |
0.891 |
0.077 |
|
rs2070529 |
0.631 |
0.631 |
0.605 |
0.605 |
- |
1 |
1 |
0.495 |
0.274 |
|
rs2070530 |
0.605 |
0.60 |
0.582 |
0.582 |
1 |
- |
1 |
0.495 |
0.269 |
|
rs2070531 |
1 |
1 |
0.741 |
0.741 |
0.631 |
0.605 |
- |
0.5 |
0.122 |
|
rs461155 |
0.125 |
0.125 |
0.350 |
0.350 |
0.204 |
0.204 |
0.125 |
- |
0.425 |
|
rs11254 |
0.013 |
0.013 |
0.001 |
0.001 |
0.041 |
0.038 |
0.013 |
0.088 |
- |
|
OC | |||||||||
|
rs6517481 |
- |
1 |
0.948 |
0.948 |
1 |
1 |
1 |
0.334 |
0.899 |
|
rs7276961 |
1 |
- |
0.948 |
0.948 |
1 |
1 |
1 |
0.334 |
0.899 |
|
rs1051475 |
0.697 |
0.697 |
- |
1 |
1 |
1 |
0.950 |
0.632 |
0.907 |
|
rs1051476 |
0.697 |
0.697 |
1 |
- |
1 |
1 |
0.950 |
0.632 |
0.907 |
|
rs2070529 |
0.607 |
0.607 |
0.471 |
0.471 |
- |
1 |
1 |
0.391 |
0.856 |
|
rs2070530 |
0.630 |
0.630 |
0.488 |
0.488 |
0.963 |
- |
1 |
0.306 |
0.861 |
|
rs2070531 |
0.960 |
0.960 |
0.728 |
0.728 |
0.582 |
0.605 |
- |
0.306 |
0.902 |
|
rs461155 |
0.060 |
0.060 |
0.168 |
0.168 |
0.137 |
0.049 |
0.049 |
- |
0.656 |
| rs11254 | 0.656 | 0.656 | 0.787 | 0.787 | 0.360 | 0.378 | 0.687 | 0.189 | - |