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. 2013 Feb 4;8(2):e55590. doi: 10.1371/journal.pone.0055590

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© 2013 Honnuraiah, Narayanan

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Schematic of the single compartment model used in this study. The various ligand- and voltage-gated channels used in the model are depicted as arrows, and the transmembrane voltage Vm was recorded in response to Poisson-modulated excitatory synaptic inputs or to pulse current injections. (B) Voltage traces (for 1 s) depicting neuronal firing for Poisson-distributed synaptic stimulation at various stimulus frequencies (SF). (C) Plot showing firing frequency (FF) as a function of SF. Data represented as mean ± SEM for 100 trials of Poisson-distributed synaptic stimulation at each SF. (D) Functional form of the plasticity-regulating (Equation 14) plotted as a function of intracellular calcium levels. (E) Synaptic plasticity was induced by stimulating the colocalized NMDAR-AMPAR synapses with 900 pulses of various induction frequencies (f _i) spanning a range of 0.5–25 Hz. Depicted are pulses for five different frequencies for a period of 1 s. As the number of pulses was set at 900 irrespective of the induction frequencies, induction of plasticity through a lower frequency pulse will run for a longer time compared to induction through a higher frequency pulse. (F) BCM-like synaptic weight (w) change induced through various induction frequencies. Arrow indicates the initiation of spikes during the induction protocol.

Inline graphic — (A) Schematic of the single compartment model used in this study. The various ligand- and voltage-gated channels used in the model are depicted as arrows, and the transmembrane voltage Vm was recorded in response to Poisson-modulated excitatory synaptic inputs or to pulse current injections. (B) Voltage traces (for 1 s) depicting neuronal firing for Poisson-distributed synaptic stimulation at various stimulus frequencies (SF). (C) Plot showing firing frequency (FF) as a function of SF. Data represented as mean ± SEM for 100 trials of Poisson-distributed synaptic stimulation at each SF. (D) Functional form of the plasticity-regulating (Equation 14) plotted as a function of intracellular calcium levels. (E) Synaptic plasticity was induced by stimulating the colocalized NMDAR-AMPAR synapses with 900 pulses of various induction frequencies (f _i) spanning a range of 0.5–25 Hz. Depicted are pulses for five different frequencies for a period of 1 s. As the number of pulses was set at 900 irrespective of the induction frequencies, induction of plasticity through a lower frequency pulse will run for a longer time compared to induction through a higher frequency pulse. (F) BCM-like synaptic weight (w) change induced through various induction frequencies. Arrow indicates the initiation of spikes during the induction protocol.