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. 2013 Feb 4;8(2):e55590. doi: 10.1371/journal.pone.0055590

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© 2013 Honnuraiah, Narayanan

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) LTD induction (15 Hz/900 pulses) resulted in a leftward shift in the FF vs. SF plot. Black: Baseline; Red: after LTD induction. (B) Minimal learning rate (Equation 40) plotted as a function of number of IPR iterations. (C) Evolution of h conductance and the corresponding mean-squared error in the FF-SF plot depicted as functions of IPR iterations. (D) FF vs. SF plots under baseline condition (black), after LTD induction (red), and after LTD induction and IPR. (E) Traces showing neuronal firing for a non-synaptic pulse current injection of 200 pA, before (black) and after IPR (green). (F) Firing frequencies for various amplitudes of non-synaptic pulse current injections (of 500 ms) shown for cases before (black) and after IPR (green). Note that the induction of LTD alone does not alter neuronal response to non-synaptic pulse current injection. = 10 nm/s and baseline = 0.15 mS/cm².

Inline graphic — (A) LTD induction (15 Hz/900 pulses) resulted in a leftward shift in the FF vs. SF plot. Black: Baseline; Red: after LTD induction. (B) Minimal learning rate (Equation 40) plotted as a function of number of IPR iterations. (C) Evolution of h conductance and the corresponding mean-squared error in the FF-SF plot depicted as functions of IPR iterations. (D) FF vs. SF plots under baseline condition (black), after LTD induction (red), and after LTD induction and IPR. (E) Traces showing neuronal firing for a non-synaptic pulse current injection of 200 pA, before (black) and after IPR (green). (F) Firing frequencies for various amplitudes of non-synaptic pulse current injections (of 500 ms) shown for cases before (black) and after IPR (green). Note that the induction of LTD alone does not alter neuronal response to non-synaptic pulse current injection. = 10 nm/s and baseline = 0.15 mS/cm².