Table 3.
Allele frequencies (af) of the more common HLA class I and II molecules found in patients with Papillon-Lefèvre Syndrome, their relatives and controls
|
Alleles |
Patients |
|
Relatives |
|
Controls |
|
|---|---|---|---|---|---|---|
| (N = 18) | (N = 30) | (N = 82) | ||||
|
HLA-A |
|
af |
|
af |
|
af |
| A*24 |
6 |
0.3333 |
8 |
0.2667 |
12 |
0.1463 |
| A*02 |
3 |
0.1667 |
4 |
0.1333 |
24 |
0.2927 |
| A*33 |
3 |
0.1667 |
2 |
0.0667 |
1 |
0.0122 |
| A*31 |
2 |
0.1111 |
5 |
0.1667 |
8 |
0.0976 |
| A*03 |
2 |
0.1111 |
2 |
0.0667 |
2 |
0.0244 |
|
HLA-B |
|
|
|
|
|
|
| B*35 |
6 |
0.3333 |
9 |
0.3000 |
17 |
0.2073 |
| B*65 |
3 |
0.1667 |
2 |
0.0667 |
2 |
0.0244 |
| B*44 |
2 |
0.1111 |
2 |
0.0667 |
9 |
0.1098 |
| B*51 |
1 |
0.0556 |
2 |
0.0667 |
4 |
0.0488 |
| B*60 |
1 |
0.0556 |
2 |
0.0667 |
3 |
0.0366 |
|
HLA-DRB1 |
|
|
|
|
|
|
| DRB1*11 |
6 |
0.3333 |
6 |
0.2000 |
6 |
0.0732 |
| DRB1*04 |
4 |
0.2222 |
9 |
0.3000 |
20 |
0.2439 |
| DRB1*01 |
3 |
0.1667 |
6 |
0.2000 |
13 |
0.1585 |
| DRB1*15 |
3 |
0.1667 |
4 |
0.1333 |
3 |
0.0366 |
| DRB1*07 |
1 |
0.0556 |
2 |
0.0667 |
8 |
0.0976 |
|
HLA-DQB1 |
|
|
|
|
|
|
| DQB1*0301 |
7 |
0.3889 |
9 |
0.3000 |
20 |
0.2439 |
| DQB1*0302 |
4 |
0.2222 |
9 |
0.3000 |
14 |
0.1707 |
| DQB1*0501 |
4 |
0.2222 |
4 |
0.1333 |
9 |
0.1098 |
| DQB1*0601 |
2 |
0.1111 |
2 |
0.0667 |
8 |
0.0976 |
| DQB1*0201 | 1 | 0.0556 | 5 | 0.1667 | 14 | 0.1707 |