Table 3.
Association of allele and genotype frequencies of OPG, RANK and RANKL in patients with breast cancer and healthy controls
| SNP | Alleles / Genotypes | Breast cancer | Healthy controls | OR (95% CI) | p-value* |
|---|---|---|---|---|---|
|
OPG rs3102735 |
|
n=614 (%) |
n=784 (%) |
|
|
| Alleles |
C |
113 (18.4%) |
102 (13.0%) |
1.508 |
0.006 |
| |
T |
501 (81.6%) |
682 (87.0%) |
(1.127-2.018) |
|
| |
|
n=307 (%) |
n=392 (%) |
|
|
| Genotypes |
CC |
10 (3.3%) |
5 (1.3%) |
|
0.019 |
| |
CT |
93 (30.3%) |
92 (23.5%) |
|
|
| |
TT |
204 (66.4%) |
295 (75.3%) |
|
|
|
OPG rs2073618 |
|
n=614 (%) |
n=786 (%) |
|
|
| Alleles |
C |
269 (43.8%) |
357 (45.4%) |
0.937 |
0.552 |
| |
G |
345 (56.2%) |
429 (54.6%) |
(0.758-1.159) |
|
| |
|
n=307 (%) |
n=393 (%) |
|
|
| Genotypes |
CC |
57 (18.6%) |
77 (19.6%) |
|
0.810 |
| |
CG |
155 (50.5%) |
203 (51.7%) |
|
|
| |
GG |
95 (30.9%) |
113 (29.7%) |
|
|
|
RANK rs1805034 |
|
n=614 (%) |
n=790 (%) |
|
|
| Alleles |
C |
291 (47.4%) |
362 (45.8%) |
1.065 |
0.590 |
| |
T |
323 (52.6%) |
428 (54.2%) |
(0.862-1.316) |
|
| |
|
n=307 (%) |
n=395 (%) |
|
|
| Genotypes |
CC |
73 (23.8%) |
78 (19.7%) |
|
0.334 |
| |
CT |
145 (47.2%) |
206 (52.2%) |
|
|
| |
TT |
89 (29.0%) |
111 (28.1%) |
|
|
|
RANK rs35211496 |
|
n=614 (%) |
n=792 (%) |
|
|
| Alleles |
T |
122 (19.9%) |
141 (17.8%) |
1.145 |
0.335 |
| |
C |
492 (80.1%) |
651 (82.2%) |
(0.875-1.499) |
|
| |
|
n=307 (%) |
n=396 (%) |
|
|
| Genotypes |
TT |
12 (3.9%) |
9 (2.3%) |
|
0.423 |
| |
TC |
98 (31.9%) |
123 (31.1%) |
|
|
| |
CC |
197 (64.2%) |
264 (66.7%) |
|
|
|
RANKL rs9533156 |
|
n=614 (%) |
n=788 (%) |
|
|
| Alleles |
C |
280 (45.6%) |
369 (46.8%) |
0.952 |
0.666 |
| |
T |
334 (54.4%) |
419 (53.2%) |
(0.770-1.176) |
|
| |
|
n=307 (%) |
n=394 (%) |
|
|
| Genotypes |
CC |
68 (22.1%) |
82 (20.8%) |
|
0.387 |
| |
CT |
144 (46.9%) |
205 (52.0%) |
|
|
| |
TT |
95 (30.9%) |
107 (27.2%) |
|
|
|
RANKL rs2277438 |
|
n=614 (%) |
n=788 (%) |
|
|
| Alleles |
G |
109 (17.8%) |
132 (16.8%) |
1.073 |
0.669 |
| |
A |
505 (82.2%) |
656 (83.2%) |
(0.812-1.418) |
|
| |
|
n=307 (%) |
n=394 (%) |
|
|
| Genotypes |
GG |
8 (2.6%) |
9 (2.3%) |
|
0.866 |
| |
GA |
93 (30.3%) |
114 (28.9%) |
|
|
| |
AA |
206 (67.1%) |
271 (68.8%) |
|
|
|
RANKL rs1054016 |
|
n=614 (%) |
n=786 (%) |
|
|
| Alleles |
T |
258 (42.0%) |
345 (43.9%) |
0.927 |
0.514 |
| |
G |
356 (58.0%) |
441 (56.1%) |
(0.749-1.147) |
|
| |
|
n=307 (%) |
n=393 (%) |
|
|
| Genotypes |
TT |
57 (18.6%) |
73 (18.6%) |
|
0.543 |
| |
TG |
144 (46.9%) |
199 (50.6%) |
|
|
| GG | 106 (34.5%) | 121 (30.8%) |
CI = confidence intervals; RANK = receptor activator of nuclear factor-κB; RANKL = RANK ligand; OPG = osteoprotegerin; OR = odds ratio; *χ2-tests for 2x2 tables (alleles) and for 2x3 tables (genotypes), respectively.