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. 2013 Feb 4;8(2):e55807. doi: 10.1371/journal.pone.0055807

Figure 2. Effects of endpoint adjudication on the results of ADVANCE blood pressure lowering arm.

Figure 2

Effects of blood pressure lowering treatment on the risks of clinical outcomes were examined based on diagnoses reported by the site investigators (SI) and those assigned by the endpoint adjudication committee (EPAC). Centers of the boxes are placed at the estimates of effect; areas of the boxes are proportional to the reciprocal of the variance of the estimates. Horizontal lines represent 95% confidence intervals (CI).