Figure 8. Possible scheme of the effects of T30 on PC12 cells.

The population of cells (1) is treated with AChE C-terminus peptide of 30 amino acids (T30), causing a reduction of 30% of the population (2) and a consequent increase in AChE release from the 70% of the extant population as a ‘compensatory’ effect (3). The released AChE could be cleaved to yield T30 which then would act at the α7-nAChR, completing a feed-forward cycle of toxicity.