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. 2013 Feb 4;200(3):337–355. doi: 10.1083/jcb.201207099

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© 2013 Lewellis et al.

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Figure 1. — TgSNs follow a dynamic SDF1a expression domain. (A–D) SDF1a (blue) and HuC (brown, TgSNs indicated by black arrows) mRNA distribution in 6-, 8-, 10-, and 12-somite-stage embryos. TgSNs are initially distributed along the anterior–posterior axis (A). They gradually move posterior (B) until they assemble in tight bilateral clusters lateral and posterior to the MHB (asterisks in A–D) by the 10-somite stage (C) and cease migration (D). SDF1a mRNA-expressing cells were often found in close association with migrating TgSNs (arrow in B), but SDF1a mRNA in this region was never detected further anterior than the anterior-most TgSN (arrowhead in B). (D–G) 6-, 8-, 10-, and 12-somite-stage embryos stained for SDF1a mRNA only so that TgSNs do not obscure the SDF1a expression domain. Shown is the dynamic SDF1a expression domain (bracket in E–H) that delineates the TgSN migration route. In relation to the anterior border of rhombomere 2 (red arrow in E–H), the anterior border of the SDF1a expression domain gradually shifted posteriorly (F and G) to come to lie posterior to the ganglion assembly site by the 10- and 12-somite stages (G and H). Arrowheads in E–H denote SDF1a mRNA expression at the site of the future olfactory placode, a location to which trigeminal sensory neurons are not normally attracted. Dorsal view, anterior to the left. See also Fig. S1. Bar, 100 µm.