Table 1.
Results of baseline quantitative sensory testing.
| ARA 290* | Placebo | ||||
|---|---|---|---|---|---|
|
|
|
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| Variable | Nerve fibers involved | Change | Number of patients (%) | Change | Number of patients (%) |
| Cold detection threshold | Aδ and C | Decrease | 7 (64) | Decrease | 9 (90) |
| Warm detection threshold | Aδ and C | Decrease | 7 (64) | Decrease | 6 (60) |
| Thermal sensory limen | Aδ and C | Decrease | 3 (27) | Decreased, increased | 2 (20), 1 (10) |
| Paradoxical heat sensation | Aδ | Decrease | 1 (9) | — | 0 |
| Cold pain threshold | Aδ and C | — | 0 | Increase | 1 (10) |
| Heat pain threshold | C | Decrease, increase | 2 (18), 1 (9) | Decrease, increase | 1 (10), 2 (20) |
| Mechanical detection threshold | Aβ | Decrease, increase | 2 (18), 1 (9) | Decrease | 1 (10) |
| Mechanical pain threshold | Aβ | Decrease | 2 (18) | Decrease | 3 (30) |
| Mechanical pain sensitivity | Aβ + C | Decrease | 1 (9) | Increase | 2 (20) |
| Dynamic mechanical allodynia | Aβ | Increase | 1 (9) | Increase | 4 (40) |
| Windup ratio | Aδ and C | — | 0 | Increase | 1 (10) |
| Vibration detection threshold | Aβ | Decrease | 6 (55) | Decrease | 6 (60) |
| Pressure pain threshold | Aδ and C | Increase | 2 (18) | Increase | 8 (80) |
*
One patient in the ARA 290 treatment arm refused QST. Patients in both treatment groups showed functional impairment in the function of both small fibers (Aδ and C) as well as larger sensory fibers (Aβ). Data are expressed as either increased or decreased function in those patients deviating 2 or more standard deviations from measurements obtained from a normal population.