Table 1.
Percentage of various lymphocyte subpopulations.
| CD4+CD8− | CD4+CD8+ | CD4−CD8− | CD4−CD8+ | |
|---|---|---|---|---|
| Blood cells | ||||
| Sham | 33.6 ± 2.8 | 12.6 ± 1.8 | 50.5 ± 3.9 | 3.3 ± 0.7 |
| CLP | 11.4 ± 0.5b | 17.4 ± 2.7 | 67.2 ± 3.7a | 4.0 ± 1.2 |
| CLP + chlorogenic acid | 21.4 ± 2.1c | 10.9 ± 2.6 | 64.6 ± 5.2 | 3.1 ± 0.8 |
| Splenocytes | ||||
| Sham | 12.3 ± 1.1 | 11.3 ± 0.1 | 69.7 ± 1.0 | 6.7 ± 0.5 |
| CLP | 5.6 ± 0.9b | 10.4 ± 1.6 | 78.3 ± 1.6b | 5.8 ± 0.6 |
| CLP + chlorogenic acid | 11.5 ± 0.5c | 11.5 ± 0.6 | 69.7 ± 1.0c | 7.3 ± 0.6 |
| Thymocytes | ||||
| Sham | 12.3 ± 0.1 | 43.0 ± 1.0 | 34.1 ± 1.0 | 10.6 ± 0.1 |
| CLP | 3.3 ± 0.1b | 65.5 ± 0.8b | 22.8 ± 0.6b | 8.3 ± 0.2 |
| CLP + chlorogenic acid | 9.5 ± 0.4c | 42.6 ± 1.2c | 39.9 ± 1.6c | 8.1 ± 0.5 |
The effect of chlorogenic acid (20 mg/kg) on lymphocyte subpopulations was determined via flow cytometry and CD markers. The results are presented as mean ± SEM. n = 5–7 per group.
a
Statistically significant differences from the sham group (P < 0.05).
b
Statistically significant differences from the sham group (P < 0.01).
c
Statistically significant differences from the vehicle-treated CLP group (P < 0.01).