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ALR secretion increases before LDH release from hepatocytes challenged with DNA damaging agent MMS. Cultured hepatocytes were incubated in the presence of 500 μmol/L MMS for the indicated time points, at which point ALR (A) and LDH (B) release, and cell viability (C), were determined. Results shown are means of triplicate determinations ± SEM from a representative of three separate experiments. *p < 0.05 versus control; **p < 0.01 versus control; ***p < 0.001 versus control.
