Figure 4.

A. Isoflurane decreases temporal variability of original data as measured by sample entropy. As we found in the Mutual Information calculations, the isoflurane did not change the Sample Entropy of the surrogate data, but it did change the Sample Entropy of the original data. A decrease in sample entropy indicates less complexity and greater predictability of a data set. The asterik denotes that the values during sedation are significantly different from both baseline and recovery values. Figure 4B. Ketamine decreases temporal variability of original and surrogate data sets. As was the case with the Mutual Information results, both the original and surrogate data sets were influenced by ketamine, despite the result that isoflurane significantly influenced on the original data.