Figure 6.
Mutual regulatory model of miR-31 and AR. MiR-31 inhibits the expression of AR and several proteins involved in cell cycle regulation and proliferation. On the other hand, AR and H3K27 trimethylation can repress miR-31 expression. During PCA pathogenesis, increased promoter methylation leads to the loss of miR-31 expression. Downregulation of miR-31 in PCA may occur as an early event in PCA resulting in increased AR expression. Alternatively, increased AR expression or activity may be a preliminary event that leads to miR-31 silencing.