Skip to main content
. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: Cancer Res. 2012 Dec 11;73(3):1232–1244. doi: 10.1158/0008-5472.CAN-12-2968

Figure 6.

Figure 6

Mutual regulatory model of miR-31 and AR. MiR-31 inhibits the expression of AR and several proteins involved in cell cycle regulation and proliferation. On the other hand, AR and H3K27 trimethylation can repress miR-31 expression. During PCA pathogenesis, increased promoter methylation leads to the loss of miR-31 expression. Downregulation of miR-31 in PCA may occur as an early event in PCA resulting in increased AR expression. Alternatively, increased AR expression or activity may be a preliminary event that leads to miR-31 silencing.

HHS Vulnerability Disclosure