Table 2.
Comparison of pre- and post-operative basal and ACTH-stimulated hormonal levels in PCOS subjects.
| Steroid | Before BSO | After BSO | Direction | P value | ||
|---|---|---|---|---|---|---|
| mean | CV(%) | mean | CV(%) | |||
| Baseline | ||||||
| DHEA0 (ng/ml) | 2.62 | 2.6 | 2.55 | 5.7 | → | NS |
| A40 (pg/ml) | 1205.5 | 6.4 | 583.06 | 5.2 | ↓ | 0.0005 |
| F0 (μg/dl) | 11.0 | 6.3 | 10.27 | 4.5 | → | NS |
| Stimulated | ||||||
| DHEA60 (ng/ml) | 6.80 | 5.1 | 6.42 | 5.6 | → | NS |
| A460 (pg/ml) | 1464.3 | 9.3 | 1158.6 | 4.3 | ↓ | 0.0419 |
| F60 (μg/dl) | 26.8 | 6.9 | 33.1 | 2.0 | ↑ | 0.0803 |
| Ratios of net increments | ||||||
| Δ DHEA | 2.59 | 5.0 | 2.52 | 5.5 | → | NS |
| Δ A4 | 1.21 | 9.2 | 1.99 | 6.2 | ↑ | 0.0026 |
| Δ F | 2.45 | 8.3 | 3.23 | 5.0 | ↑ | 0.0527 |
Values depicted for baseline and for stimulated values represent the anti-log of the geometric means based on the log scale used for analysis. Values depicted for ratios of net increments represent the ratios of the 60 min/base values obtained using the log scale 60 min value minus base value.
Abbreviations: A4 is androstenedione; BSO is bilateral salpingo-oophorectomy; DHEA is dehydroepiandrosterone; F is cortisol; Steroid0 represents baseline level; Steroid60 represents post-ACTH stimulation level; and ΔSteroid represents the net change in steroid levels in response to acute ACTH(1–24) stimulation, i.e. basal minus stimulated level; and CV(%) is percent coefficient of variation, equal the SD divided by the mean (x 100).