Table 2.

Cox proportional hazards models - snoring and incident cardiovascular disease among Women’s Health Initiative study participants (N=42,244)^§

	Snoring frequency			Model adjusted for age, race			Model fully adjusted†
		Cases	Person-years	HR	95% CI	P-value	HR	95% CI	P-value
CHD*	Frequent	609	86,227	1.54	1.39, 1.70	<0.001	1.14	1.01, 1.28	0.038
	Occasional	814	143,209	1.27	1.16, 1.39	<0.001	1.12	1.01, 1.24	0.032
	None (referent)	978	208,454	1.00	REF	REF	1.00	REF	REF
CVD‡	Frequent	790	84,671	1.46	1.34, 1.60	<0.001	1.12	1.01, 1.24	0.031
	Occasional	1103	141,122	1.25	1.16, 1.36	<0.001	1.11	1.01, 1.21	0.026
	None (referent)	1354	205,547	1.00	REF	REF	1.00	REF	REF
Ischemic Stroke	Frequent	232	95,307	1.41	1.19, 1.66	<0.001	1.19	1.02, 1.40	0.030
	Occasional	349	153,389	1.29	1.11, 1.50	<0.001	1.15	0.96, 1.38	0.140
	None (referent)	412	220,697	1.00	REF	REF	1.00	REF	REF

^*Total CHD outcome includes MI, CHD death, PTCA, CABG, or hospitalized angina

^†CVD outcome includes MI, CHD death, PTCA, CABG, hospitalized angina, or ischemic stroke

^‡Model adjusted for age, race, education, income, smoking, physical activity, alcohol intake, depression, diabetes, high blood pressure, BMI, WHR, hyperlipidemia

^§All analyses conducted among disease-free cohort and total N’s reflect this difference by outcome