Table 4.

Sensitivity analysis - Cox proportional hazards models of snoring and incident cardiovascular disease among Women’s Health Initiative participants using inverse probability weighting (N=42,244)^§

	Snoring frequency			Model adjusted for age, race			Model fully adjusted†
		Cases	Person-yrs	HR	95% CI	P-value	HR	95% CI	P-value
CHD*	Frequent	609	86,227	1.59	1.42, 1.78	<0.001	1.16	1.03, 1.30	0.018
	Occasional	814	143,209	1.28	1.16, 1.42	<0.001	1.12	1.00, 1.24	0.043
	None (referent)	978	208,454	1.00	REF	REF	1.00	REF	REF
CVD‡	Frequent	790	84,671	1.49	1.35, 1.65	<0.001	1.13	1.02, 1.25	0.018
	Occasional	1103	141,122	1.26	1.15, 1.38	<0.001	1.12	1.02, 1.23	0.026
	None (referent)	1354	205,547	1.00	REF	REF	1.00	REF	REF
Stroke	Frequent	232	95,307	1.37	1.15, 1.64	0.001	1.21	1.03, 1.43	0.020
	Occasional	349	153,389	1.30	1.11, 1.52	0.002	1.14	0.94, 1.37	0.178
	None (referent)	412	220,697	1.00	REF	REF	1.00	REF	REF

^*CHD outcome includes MI, CHD death, PTCA, CABG, or hospitalized angina

^‡CVD outcome includes MI, CHD death, PTCA, CABG, hospitalized angina, or ischemic stroke

^†Model adjusted for age, race, education, income, smoking, physical activity, alcohol intake, depression, diabetes, high blood pressure, BMI, WHR, hyperlipidemia

^§All analyses conducted among disease-free cohort and total N’s reflect this difference by outcome