Fig. 3.
MRI-based concentration maps (a) after Ho-PLLA-MS administration, MRI-based absorbed dose maps (b) together with their corresponding SPECT images (c) and T1-weighted images (d) (TR/TE: 8.5 ms/4.18 ms, flip angle: 10°). The concentration maps were constructed from normalised R*2 maps by using the r*2 relaxivity of Ho-PLLA-MS. MRI-based dose maps were constructed by applying a dose point kernel after conversion of concentrations Ho-PLLA-MS to MBq/voxel. MRI-based concentration and absorbed dose correspond to the activity distribution on the SPECT images (c) and the tumour sites on T1-weighted images (d) (arrows)