Figure 5.

AQ2S inhibits initiator and executioner caspases. Primary rat cortical neurons were seeded onto 96-well plates. Neurons were treated with+150 nℳ STS and+75 μM AQ2S for 24 h. Graphs show caspase activity (relative luminescent units, RLU) for (a) caspase-3/7 (n=6/treatment group) (b) caspase-8 (n=6/treatment group), and (c) caspase-9 (n=6/treatment group). Data was analyzed using one-way-ANOVA (P<0.0001 for all graphs; graphs show mean+S.E.M.). Asterisks indicate significant (P<0.05) results of Fisher LSD post-hoc test