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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: J Allergy Clin Immunol. 2013 Feb;131(2):491–500.e5. doi: 10.1016/j.jaci.2012.11.037

Figure 2. IgE cross-linking induces monocyte secretion of TNFá, IL-6, and autoregulatory IL-10.

Figure 2

A. TNFα (left), IL-6 (middle), and IL-10 (right) concentrations in indicated monocyte culture conditions after 4, 24, or 48 hr (N≥9). B. Similar data for monocytes cultured with αIgE in the presence of IL-10 and IL-10R neutralizing antibodies or isotype control (N=3). C. IL-10 concentration after 48 hr of IgE cross-linking on monocytes from individuals with low (<100 U/ml) or high (>100 U/ml) serum IgE (left) and corresponding Pearson correlation (right; N=12). D. Concentration of TNFα after 4 hr (left); IL-6 after 48 hr (right) of IgE cross-linking on monocytes from individuals with low vs. high serum IgE (N≥10). * p<.05, ** p<.01, *** p<.001 for αIgE vs. Media and IgG (A), Blocking Antibodies vs. Isotype (B), or High IgE vs. Low IgE (C,D).