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. 2013 Jan 8;5(1):54–86. doi: 10.3390/v5010054

Figure 4.

Figure 4

(a) Diagram of RB69 Fingers domain showing location of ABC block mutation relative to dNTP binding residues. Motif B residues are in orange, Tri-phosphate interacting residues on Helix N are in yellow, Block A is in red, Block B is in dark blue and Block C is in yellow. Aligned image of pdb 3LDS (dNTP) and pdb 3KD5 (N and P helix). (b) Sequence alignment of RB69 and herpesviridae sequences showing location of block mutations. (c) Diagram showing clash between W478 of Block A and W365. RB69 ABC5 is in white (3KD5), RB69 WT is in blue (pdb 1IH7) and HSV1 UL30 is in orange (pdb 2GV9). (d) Diagram of RB69 ABC5 block mutations active site showing phosphonoformic acid binding in β and γ phosphate position and with acyclovir in the pre-translocation position (pdb 3KD5). Images were generated using Pymol [23]. Alignment was generated using Geneious [24].