Table 1.

Comparison of size, weight and position of conserved motifs or active site residues of RB69 and herpesviridae DNA polymerases. The position conserved motifs where assigned based on alignments generated using geneious [24].

Virus (Gene)	Amino Acids (aa)	Weight (kDa)	FYNPYL motif	Exo 1	Exo2/region IV	Exo3/delta (ä) C	Motif A/region II	Motif B/region III	Motif C/region I	KKRY motif
RB69 (gp43)	903	104.47	N/A	113–117	222	327	411–420	560–571	621–624	804–807
HSV1 (UL30)	1236	136.42	167–173	367–371	471	581	717–726	811–822	886–889	938–941
HSV2 (UL30)	1241	137.32	166–172	368–372	472	582	722–731	816–827	891–894	943–946
VZV (Orf28)	1195	134.05	7–13	348–352	452	562	682–691	775–786	851–854	903–906
EBV (BALF5)	1016	113.43	6–12	295–299	384	497	584–593	681–692	755–758	807–810
HCMV (UL54)	1242	137.21	2–8	300–304	413	542	717–726	811–822	910–913	962–965
HHV6 (UL38)	1013	115.67	6–12	281–285	369	482	572–581	666–677	740–743	792–795
HHV7 (UL38)	1014	115.91	6–12	280–284	368	480	572–581	666–677	740–743	792–795
KSHV (Orf9)	1013	113.33	3–9	295–299	383	498	585–594	681–692	752–755	804–807