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. 2013 Jan 17;5(1):241–278. doi: 10.3390/v5010241

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© 2013 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).

PMC Copyright notice

Predicted ML29 host-specific changes in NP. The left-most structure shows the ML29 NP predicted structure after passage in Vero cells. The middle structure represents the predicted NP changes (M179L, D341G, R551K) occurring in virus recovered from rhesus macaques only. The structure on the left shows two changes (R59R, and T223A) seen in mouse and marmosets. All host-specific mutations induced conformational changes in the NP predicted structure. The structure goes from N-terminus (blue) to C-terminus (red).