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. 2013 Jan 10;11(1):99–113. doi: 10.3390/md11010099

Figure 4.

Figure 4

The effects of lemnalol on synovial iNOS and COX-2 protein expression in rats with MSU-induced arthritis. iNOS staining of synovial sections at 24 h after normal saline injection (A); MSU injection (B); MSU + colchicine injection (C); and MSU + lemnalol injection (D); MSU-induced synovitis was associated with upregulated iNOS protein expression. There were markedly fewer immunopositive cells in the lemnalol-treated group. The upregulation of iNOS-immunoreactive cells was inhibited in the lemnalol-treated group. Synovial sections obtained at 24 h after normal saline injection (E); MSU injection (F); MSU + colchicine injection (G); and MSU + lemnalol injection (H) and subsequently stained for COX-2. MSU-induced synovitis was associated with increased COX-2 protein expression. There were markedly fewer inflammatory cells in the lemnalol-treated group. The upregulation of COX-2-immunoreactive cells was inhibited in the lemnalol-treated group. Scale bars: 50 μm for all images.