Table 1. Mean values and s.d.'s of measured and calculated variables during experimental maneuvers.
|
Intracranial hypertension (N=29) |
Arterial hypotension (N=10) |
Changes in PaCO2(N=8) |
|||||||
|---|---|---|---|---|---|---|---|---|---|
| Baseline ICP | High ICP | P-value | Baseline ABP | Low ABP | P-value | <40 mm Hg | >40 mm Hg | P-value | |
| ICP (mm Hg) | 9.17±5.31 | 33.70±12.40 | <0.001 | 8.21±6.94 | 10.7±5.07 | 0.026 | 9.36±4.93 | 13.64±4.80 | 0.123 (NS) |
| ABP (mm Hg) | 92.47±17.50 | 93.73±19.62 | 0.523 (NS) | 101.47±21.58 | 68.09±19.75 | <0.001 | 88.17±11.59 | 103.65±11.88 | 0.025 |
| CPP (mm Hg) | 83.30±16.31 | 60.02±16.43 | <0.001 | 93.26±18.93 | 57.39±20.61 | <0.001 | 81.05±15.27 | 95.22±11.74 | 0.050 |
| FV (cm/second) | 19.00±7.71 | 15.87±8.05 | <0.001 | 21.29±5.45 | 12.15±3.01 | 0.001 | 12.15±7.78 | 21.11±7.46 | 0.010 |
| CCP1 (mm Hg) | 53.36±21.44 | 67.85±16.08 | <0.001 | 65.34±17.05 | 56.17±14.09 | 0.006 | 58.92±16.05 | 54.92±16.67 | 0.161 (NS) |
| CCPm (mm Hg) | 58.75±14.57 | 70.99±14.57 | <0.001 | 67.71±16.84 | 56.03±13.85 | 0.002 | 59.19±11.96 | 59.15±10.13 | 0.889 (NS) |
| CCPm–CCP1 (mm Hg) | 5.56±9.78 | 3.25±5.40 | 0.048 | 2.58±1.73 | 5.34±17.25 | 0.176 | 0.74±5.16 | 4.83±7.51 | 0.017 |
| WT1 (mm Hg) | 44.19±21.75 | 34.14±15.56 | <0.001 | 57.13±16.89 | 45.47±15.14 | <0.001 | 48.14±16.88 | 40.42±16.49 | 0.123 (NS) |
| WTm (mm Hg) | 49.58±14.36 | 37.28±12.23 | <0.001 | 59.50±16.17 | 45.33±14.80 | <0.001 | 48.41±13.33 | 48.21±9.76 | 0.306 (NS) |
Abbreviations: ICP, intracranial pressure; ABP, arterial blood pressure; CPP, cerebral perfusion pressure; FV, flow velocity; CCP1, first harmonic model of critical closing pressure; CCPm, multiparameter mathematical model of critical closing pressure; WT1, first harmonic model of wall tension; WTm, multiparameter mathematical model of wall tension.