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. 2012 Dec 5;33(2):300–310. doi: 10.1038/jcbfm.2012.172

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Copyright © 2013 International Society for Cerebral Blood Flow & Metabolism, Inc.

This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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Treatment with cocaine- and amphetamine-regulated transcript (CART) increased cell proliferation in subventricular zone (SVZ) in stroke rats. (A) BrdU immunoreactivity was enhanced in SVZ bilaterally in a stroke animal receiving intranasal CART (lower panels), compared with vehicle (upper panels). (B) CART treatment increased Musashi-1 immunoreactivity bilaterally in SVZ in stroke animals (lower panels). (C) Photomicrographs demonstrate that CART treatment increased proliferating cell nuclear antigen (PCNA) immunostaining in the anterior subependymal zone of a stroke rat (right panel). (A–C) Calibration=100 μm. (D–F) In all animals studied, intranasal treatment with CART significantly enhanced (D) BrdU and (E) Musashi-1 immunoreactivity in SVZ. Data in (D, E) were normalized to the mean immunoreactivity in the left SVZ of stroke rats. (F) Density of PCNA-positive cells in the anterior subependymal zone was significantly increased by CART in stroke rats as determined by the Cavalieri method using unbiased stereological analysis. *P<0.05. (G) Timeline of treatment.