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letter
. 2012 Dec 5;33(2):171–174. doi: 10.1038/jcbfm.2012.181

Figure 1.

Figure 1

5′-Adenosine monophosphate (AMP) induces hypothermia in mice by activating hypothalamic adenosine A1 receptor (A1R). (A) Effects of different doses of AMP on body temperature (Tb). The effect of DPCPX (0.1 mg/kg intraperitoneally, 5 minutes pretreatment) on hypothermia by 50 mg/kg AMP is also shown. (B) Effects of AMP on blood pressure in mice. (C) Effects of the 5′-nucleotidase inhibitor AMPCP injected intracerebroventricularly on Tb of mice. The hypothermic effect or AMP (50 mg/kg intraperitoneally) is shown for comparison. (C, inset) Effect of DPCPX (0.1 mg/kg intraperitoneally) on hypothermia by AMPCP (50 μg intracerebroventricularly) 40 minutes after drug injection. (D) Effects of AMPCP on blood pressure in mice. Drugs were injected at T=0 (A, C) or T=5 minutes (B, D arrow). For all graphs, each point/column represents the mean±s.e.m., at least eight animals per group were used. *P<0.05, ***P<0.001 versus vehicle.