Table 1.

Summary of subunit vaccine development against B. pseudomallei.

References	Subunits	Immunization		Challenge				Percentage survived
		Dosage and duration	Route	Animal model	Strain	Route	Dosage
Nelson et al. (2004)	Capsular polysaccharide	3 doses in 28 days	Intraperitoneal	BALB/c	NCTC 4845	Intraperitoneal	2 × 105	0% at day 28
	Lipopolysaccharide	3 doses in 28 days	Intraperitoneal	BALB/c	NCTC 4845	Intraperitoneal	2 × 105	50% at day 35
Harland et al. (2007)	ATP binding cassette protein, LolC	3 doses in 28 days	Intraperitoneal	BALB/c	K96243	Intraperitoneal	4 × 104	80% at day 42
	Periplasmic binding protein, PotF	3 doses in 28 days	Intraperitoneal	BALB/c	K96243	Intraperitoneal	4 × 104	50% at day 42
	Oligopeptide binding protein, OppA	3 doses in 28 days	Intraperitoneal	BALB/c	K96243	Intraperitoneal	4 × 104	22% at day 42
Legutki et al. (2007)	Peptide mimotopes of exopolysaccharide	2 doses in 14 days	Intravenous	BALB/c	NCTC 4845	Intraperitoneal	4.7 × 104	0% at day 30
Druar et al. (2008)	BipB, BipC, and BipD proteins	Single dose	Intraperitoneal	BALB/c	Ashdown	Intraperitoneal	970	0% at day 5
Hara et al. (2009)	Outer membrane proteins Omp3 and Omp7	3 doses in 9 weeks	Intraperitoneal	BALB/c	D286	Intraperitoneal	1 × 106	50% at day 21
Su et al. (2010)	Outer membrane protein Omp85	3 doses in 42 days	Intraperitoneal	BALB/c	D286	Intraperitoneal	1 × 106	70% at day 15
Ngugi et al. (2010)	B. thailandensis lipopolysaccharide	3 doses in 28 days	Intraperitoneal	BALB/c	K96243	Intraperitoneal	2 × 104	50% at day 35
Burtnick et al. (2011)	Integral surface associated component of type VI secretion system, Hcp1	3 doses in 14 days	Intraperitoneal	Syrian Hamster	K96243	Intraperitoneal	5 × 104	50% at day 42
	Integral surface associated component of type VI secretion system, Hcp2	3 doses in 14 days	Intraperitoneal	Syrian Hamster	K96243	Intraperitoneal	5 × 104	80% at day 42
	Integral surface associated component of type VI secretion system, Hcp3	3 doses in 14 days	Intraperitoneal	Syrian Hamster	K96243	Intraperitoneal	5 × 104	50% at day 42
	Integral surface associated component of type VI secretion system, Hcp4	3 doses in 14 days	Intraperitoneal	Syrian Hamster	K96243	Intraperitoneal	5 × 104	33% at day 42
	Integral surface associated component of type VI secretion system, Hcp5	3 doses in 14 days	Intraperitoneal	Syrian Hamster	K96243	Intraperitoneal	5 × 104	0% at day 42
	Integral surface associated component of type VI secretion system, Hcp6	3 doses in 14 days	Intraperitoneal	Syrian Hamster	K96243	Intraperitoneal	5 × 104	50% at day 42
Nieves et al. (2011b)	Outer membrane vesicle	3 doses in 42 days	Intranasal	BALB/c	1026b	Aerosol	1 × 103	20% at day 14
			Subcutaneous	BALB/c	1026b	Aerosol	1 × 103	60% at day 14