Table 1.
Characterization data for generation 4 PAMAM thiol conjugates G4-NAP and G4-NACys and NO storage efficiency once converted to the corresponding S-nitrosothiol NO donors.
Dendrimer | # thiols/mol | Molecular Weight | NO Storage Efficiency | |||||
---|---|---|---|---|---|---|---|---|
Ellman’s | 1H NMR | MALDI | SEC | % multimer | Mw/Mn | μmol NO·mg−1 | % yield | |
G4-NAP | 62 ± 2 | 63 | 23,000 | 23,700 | 20% | 1.03 ± 0.15 | 1.7 ± 0.2 | 79% |
G4-NACys | 49 ± 4 | 58 | 21,200 | 20,630 | 16% | 1.04 ± 0.11 | 2.1 ± 0.2 | 87% |