. Author manuscript; available in PMC: 2013 Feb 5.

Published in final edited form as: Biomacromolecules. 2008 Feb 5;9(3):834–841. doi: 10.1021/bm7011746

Table 2.

Kinetic parameters for NO-release from generation 4 PAMAM nitrosothiol conjugates G4-SNAP and G4-NACysNO as a function decomposition trigger and concentration.

G4 Dendrimer	Trigger		t_1/2 (min)	[NO]_m (ppb/mg)	t_m (min)
G4 Dendrimer	type	[conc]	t_1/2 (min)	[NO]_m (ppb/mg)	t_m (min)
G4-SNAP	Cu²⁺	0.2 mM	2.3	63000	1.1
		0.6 mM	2.2	58700	1.3
		1 mM	1.5	92100	0.9
	light	60 W	200	1990	7.5
		100 W	97	2360	9.5
		200 W	34	5800	2.0
	37 °C	--	ND	158	6.4

G4-NACysNO	Cu²⁺	0.2 mM	106	2510	2.6
		0.6 mM	16	15900	3.1
		1 mM	7	26200	2.7
	light	60 W	97	1480	10.1
		100 W	90	1790	24.4
		200 W	49	2210	27.4
	37 °C	--	ND	116	8.8