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. 2012 Dec 25;4(1):57–65. doi: 10.7150/jca.5048

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© Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.

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Evolutionary relationship between IL-10 family members. IL-22, IL-20, IL-24 and IL-26 belong to IL-10 family of cytokines. Phylogenetic tree indicates the evolutionary relationship of IL-10 family members among different species. This tree was generated using PhylomeDB alignment program software based on distance-matrix and amino acid sequences of murine IL-22. Dendrogram generated using UPGMA method with a 'Systematic tie breaking' based on the percent differences between amino acid sequences. Distances were calculated using an uncorrected 'p' and gaps distributed proportionately among different amino acid sequences. The number below the dendrogram represents the unit change in the amino acid sequences among indicated species.