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IL-22 and IL-10 receptors evolved to utilize shared subunits. IL-10 and IL-22 receptors are composed of heterodimeric chains. IL-10 is made up of IL-10R1 and IL-10R2. IL-22 receptor complex consists of IL-22R1 and IL-10R2. The unique signaling and the functional outcome of these two cytokines are maintained by the exclusive use of independent receptor subunits.
