Table 1.
Clinical data of the combinational use of oxymatrine with 3TC for the treatment of HBV infection.
| Data sources | Groups and dosages | Number of cases | Course of treatment (months) | Rate of ALT normalization (%) | Rate of HBeAg negative conversion (%) | Rate of HBV-DNA negative conversion (%) |
|---|---|---|---|---|---|---|
| Song [6] | 3TC(100#) + Omt(400) | 32 | 3 | 78.1 | 46.9 | 90.6 |
| 3TC(100) | 30 | 3 | 50.0 | 16.7 | 86.7 | |
|
| ||||||
| Fan [7] | 3TC(100) + Omt(400) | 32 | 3 | 25 | 15 | 29 |
| 3TC(100) | 30 | 3 | 15 | 5 | 26 | |
|
| ||||||
| Duan [8] | 3TC(100) + Omt(600) | 60 | 6 | — | 53.3 | 63.3 |
| 3TC(100) | 60 | 6 | — | 18.3 | 23.3 | |
|
| ||||||
| Zhang [9] | 3TC(100) + Omt(600) | 62 | 6 | — | 53.23 | 62.90 |
| 3TC(100) | 62 | 6 | — | 19.35 | 24.19 | |
|
| ||||||
| Xie [10] | 3TC(100) + Omt(150) | 78 | 6 | 100 | 53.8 | 55.1 |
| 3TC(100) | 42 | 6 | 90.5 | 45.2 | 47.6 | |
|
| ||||||
| Liu [11] | 3TC(100) + Omt(400) | 31 | 12 | 100 | 61.3 | 87.1 |
| 3TC(100) | 34 | 12 | 100 | 37.1 | 85.7 | |
|
| ||||||
| Su [12] | 3TC(100) + Omt(300★) | 30 | 12 | 91.23 | 66.67 | 86.67 |
| 3TC(100) | 30 | 12 | 68.26 | 43.33 | 63.33 | |
|
| ||||||
| Chen [13] | 3TC(100) + Omt(200) | 38 | 12 | — | 11 | 23 |
| 3TC(100) | 34 | 12 | — | 7 | 16 | |
#The dosage unit is mg/day.
★The dosage of the former three months is 600 mg/day by intravenous administration, and the dosage of the followed nine months is 300 mg/day by oral administration.
—: the data were not reported in the original literatures.