Table II.
Associations of rs4939827 with tumor phenotypesa
| Controls | Cases | OR (95% CI) | Cases | OR (95% CI) | Case-only analysis | |
|---|---|---|---|---|---|---|
| pT1/pT2 | pT3/pT4 | pT3/pT4 versus pT1/pT2 | ||||
| TT | 600 | 155 | 1 | 200 | 1 | 1 |
| TG | 1120 | 241 | 0.84 (0.65–1.10) | 363 | 1.19 (0.93–1.53) | 1.54 (1.10–2.15) |
| GG | 538 | 95 | 0.51 (0.36–0.72) | 182 | 1.14 (0.85–1.53) | 2.31 (1.50–3.56) |
| P trend | 2.8 × 10−4 | 0.38 | 1.0 × 10−4b | |||
| G allelec | 0.73 (0.62–0.87) | 1.07 (0.92–1.23) | 1.52 (1.23–1.88) | |||
| N0 | N1-2 | N1-2 versus N0 | ||||
| TT | 600 | 236 | 1 | 114 | 1 | 1 |
| TG | 1120 | 407 | 1.10 (0.87–1.38) | 191 | 0.88 (0.65–1.20) | 0.79 (0.55–1.14) |
| GG | 538 | 190 | 0.84 (0.63–1.11) | 81 | 0.71 (0.49–1.04) | 0.83 (0.53–1.31) |
| P trend | 0.27 | 0.08 | 0.36 | |||
| G allele | 0.93 (0.81–1.06) | 0.85 (0.70–1.02) | 0.90 (0.72–1.13) | |||
| M0 | M1 | M1 versus M0 | ||||
| TT | 600 | 358 | 1 | 40 | 1 | 1 |
| TG | 1120 | 622 | 1.04 (0.85–1.27) | 68 | 0.90 (0.56–1.44) | 0.88 (0.54–1.44) |
| GG | 538 | 287 | 0.84 (0.66–1.07) | 26 | 0.70 (0.39–1.26) | 0.78 (0.41–1.46) |
| P trend | 0.20 | 0.24 | 0.43 | |||
| G allele | 0.93 (0.82–1.04) | 0.84 (0.63–1.12) | 0.88 (0.64–1.20) | |||
| Moderately or well-differentiated tumors | Poorly differentiated tumors | Poorly versus moderately well differentiated tumors | ||||
| TT | 600 | 299 | 1 | 56 | 1 | 1 |
| TG | 1120 | 494 | 1.00 (0.81–1.24) | 104 | 1.01 (0.66–1.54) | 1.08 (0.68–1.69) |
| GG | 538 | 235 | 0.85 (0.66–1.10) | 50 | 0.95 (0.57–1.57) | 1.28 (0.74–2.21) |
| P trend | 0.23 | 0.84 | 0.39 | |||
| G allele | 0.93 (0.82–1.05) | 0.98 (0.76–1.25) | 1.13 (0.86–1.48) | |||
| Colon cancer | Rectal cancer | Rectum versus colon | ||||
| TT | 600 | 118 | 1 | 36 | 1 | 1 |
| TG | 1120 | 233 | 1.14 (0.86–1.52) | 66 | 1.03 (0.65–1.64) | 0.90 (0.55–1.49) |
| GG | 538 | 90 | 0.84 (0.59–1.18) | 28 | 0.83 (0.48–1.45) | 0.88 (0.48–1.62) |
| P trend | 0.36 | 0.54 | 0.66 | |||
| G allele | 0.92 (0.78–1.09) | 0.92 (0.70–1.20) | 0.93 (0.69–1.27) | |||
| Age of diagnosis >60 years | Age of diagnosis <60 years | <60 versus >60 years | ||||
| TT | 600 | 337 | 1 | 80 | 1 | 1 |
| TG | 1120 | 598 | 1.04 (0.85–1.28) | 134 | 0.96 (0.65–1.40) | 0.83 (0.52–1.33) |
| GG | 538 | 263 | 0.83 (0.65–1.07) | 67 | 0.95 (0.61–1.48) | 1.19 (0.68–2.08) |
| P trend | 0.18 | 0.81 | 0.63 | |||
| G allele | 0.92 (0.82–1.04) | 0.97 (0.78–1.21) | 1.07 (0.81–1.42) | |||
aORs and P-values are adjusted for age at sample collection, race, gender, regular aspirin use, regular NSAIDs use, BMI, physical activity, history of CRC in a parent or sibling, smoking status, alcohol consumption, consumption of beef, pork or lamb as a main dish, energy-adjusted calcium and folate intake and type of sample (more details in the text).
bBH-adjusted P-value = 0.0014.
cLog-additive model, representing the OR for each additional G allele as compared with TT.