Table IV.
Mediation and interaction analysis of RUNX3 methylation in the association of rs4939817 with pT stage
| Association with pT3/4 stage | OR (95% CI) | P-value | ||
|---|---|---|---|---|
| 2.12 (1.18–3.80) | 0.0120 | |||
| Mediation analysis | TG versus TT | GG versus TT | ||
| OR (95% CI) | P-value | OR (95% CI) | P-value | |
| Direct effect | 1.96 (1.18–3.25) | 0.0088 | 4.46 (1.19–16.6) | 0.038 |
| Indirect effect | 1.05 (0.96–1.15) | 0.32 | 1.50 (0.44–5.10) | 0.51 |
| Marginal total effect | 2.06 (1.22–3.46) | 0.0068 | 6.70 (0.89–50.35) | 0.064 |
| Proportion mediated, % | 9.3 | 39.2 | ||
| Interaction analysis | ||||
| Additive | RERIa (95% CI) | P-value | ||
| 0.48 (−1.42 to 2.37) | 0.62 | |||
| Multiplicative | OR (95% CI) | P-value | ||
| 0.93 (0.39–2.19) | 0.87 |
aRERI (also known as ‘interaction contrast ratio’).